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Xenical - a potent, particular, and reversible inhibitor of gastrointestinal lipases, which has a long-lasting effect. Its therapeutic impact is accomplished inside the lumen of the stomach and small intestine. It is composed inside the formation of a covalent bond with the lively serine portion of the gastric and pancreatic lipases. The inactivated enzyme on the identical time loses the potential to break down food fat coming within the shape of triglycerides, to sucking free fatty acids and monoglycerides. Because uncleaved triglycerides are not absorbed, the resulting decrease within the consumption of calories into the frame ends in a reduction in frame weight. Consequently, the therapeutic effect of the drug is done without absorption into the systemic stream.

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Uses

Drug uses

Xenical is a gastrointestinal lipase inhibitor, used to treat obesity and obese in patients with BMI* ? 30 kg/m2 or BMI ? 27 kg/m2 with associated risk factors (excess visceral fat, hypertension, diabetes).
Xenical also can be used for reducing the danger of weight regain in overweight patients after prior weight reduction. Xenical is recommended in combination with a reduced-calorie diet and physical exercise in adults and children elderly 12 years or older.
Xenical gains comparing to other anti-weight problems tablets is this remedy isn't absorbed from the digestive tract and does now not enter the systemic blood. Therefore, Xenical is appropriately tolerated and does no longer reason any extraordinary aspect results in sufferers.
The advocated dose of Xenical is 120mg 3 instances a day all through the principle meal or inside one hour after it.
* BMI is defined as the frame mass divided by using the rectangular of the body top.

Missed dose

In the course of the remedy of obesity with Xenical, a missed dose does no longer has a severely damaging effect on the therapy of excess weight. But, the sufferers are suggested not to overlook the treatment of the drug and to take it in line with the scheduled dosing routine.
If the affected person has forgotten to take Xenical on time, he/she have to bypass the missed dose and await the next meal intake. Do no longer double the dose of Xenical to make up for an ignored dose, as it could cause facet outcomes.

More Information

The daily dose of Xenical isn't endorsed to be improved (more than 360mg) because it does not grow the therapeutic effect.
The opportunity of damaging reactions from the gastrointestinal tract can be accelerated if the patient is taking Xenical with excessive-fat ingredients. Consequently, the affected person is recommended to control caloric consumption to reduce any hazard of damaging effects.
In patients with kind 2 diabetes, a dose of hypoglycemic marketers (for example, sulfonylureas) can be required to be reduced.

Storage

It is advocated to hold Xenical in an original container or package to shield drugs from moisture and light. Keep Xenical drugs at room temperature below 30°C and out of the attain of youngsters.

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